Two sample MR report
HLA-DQB1_Monocyte (Mono) against UKB-b-18436
Date: 13 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 26 | -0.0657930 | 0.0699343 | 0.3561898 |
| Weighted median | 26 | 0.0757056 | 0.0133954 | 0.0000000 |
| Inverse variance weighted | 26 | 0.0794609 | 0.0116007 | 0.0000000 |
| Simple mode | 26 | 0.1244650 | 0.0355830 | 0.0017749 |
| Weighted mode | 26 | 0.1152433 | 0.0387914 | 0.0064756 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 42.82838 | 24 | 0.0104053 |
| Inverse variance weighted | 50.71763 | 25 | 0.0017367 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| 0.0457372 | 0.0217526 | 0.0461723 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0.0003633 | 2e-07 | TRUE | 0.0755873 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
